Inhibition of amyloid precursor protein processing by -secretase through site-directed antibodies
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چکیده
منابع مشابه
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24-204), expressed and characterized from Escherichia coli, is a competitive inhibitor of human ADAM9 catalytic/disintegrin domain with an overall inhibition constant of 280 ± 34 nM an...
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Fiona FLOOD*, Suzanne MURPHY†, Richard F. COWBURN*, Lars LANNFELT‡, Brian WALKER§ and Janet A. JOHNSTON†1 *Karolinska Institute, Neurotec Department, Division of Experimental Geriatrics, Huddinge, S-14186, Sweden, †Queen’s University, Belfast, School of Biology and Biochemistry, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, U.K., ‡Uppsala University Hospital, Depar...
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-Secretase (BACE, Asp-2) is a transmembrane aspartic proteinase responsible for cleaving the amyloid precursor protein (APP) to generate the soluble ectodomain sAPP and its C-terminal fragment CTF . CTF is subsequently cleaved by -secretase to produce the neurotoxic synaptotoxic amyloidpeptide (A ) that accumulates in Alzheimer’s disease. Indirect evidence has suggested that amyloidogenic APP p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0502427102